2008•Unpublished venueRequires access
Effects of fluvastatin on the expression of transforming growth factor β1 in the kidney of diabetic rats
Hua Shui, Qun Wang
Open publisher page 0 citations
Abstract
Objective To study the protective effects of fluvastatin on the renal lesions in diabetic rat. Methods The model of diabetic rats was induced by streptozotocin. SD rats were random divided into four groups: Control group, diabetic rats group, low-dose fluvastatin group 2mg/(kg·d) and high-dose fluvastatin group 4 mg/(kg·d). After treatment for 4 weeks, serum cholesterol, serum creatinine and urinary protein were measured respectively. The expression of TGF β1 in the renal cortex was determined by RT-PCR. Results Fluvastatin inhibited the expression of TGF-β1 Mrna in a dose-dependent manner, and had no influence on urinary protein, serum cholesterol and serum creatinine. Conclusions Fluvastatin inhibits the overexpression of TGF-β1 Mrna, which may be related to independent cholesterol decreasing effect.
Key words:
Diabetes mellitus; Pravastatin/PD; Kidney/DE