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Effects of Fluvastatin on the Expression Nuclear Factor-kappa B in the Kidney of Diabetic Rats

Hong Xia

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Abstract

Objective: To study the protective effects of fluvastatin on the kidneys of diabetic rats.Methods: The models of diabetic rats were induced by streptozotocin.SD rats were randomly divided into three groups as control group,diabetic group and fluvastatin treated group.After four weeks,blood glucose,serum cholesterol and urinary protein were measured respectively.The expression of NF-κB in the glomerulus was determined by immunohistochemical staining.Results: Fluvastatin did not influence blood glucose and serum cholesterol,but significantly inhibited the expression of NF-κB and lowered urinary protein excretion.Conclusion: Fluvastatin could protect the kidneys of diabetic rats probably through inhibiting the overexpression of NF-κB,independent of cholesterol-lowering effects.

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What this paper is about

Objective: To study the protective effects of fluvastatin on the kidneys of diabetic rats.Methods: The models of diabetic rats were induced by streptozotocin.SD rats were randomly divided into three groups as control group,diabetic group and fluvastatin treated group.After four weeks,blood glucose,serum cholesterol and urinary protein were measured respectively.The expression of NF-κB in the glomerulus was determined by immunohistochemical staining.Results: Fluvastatin did not influence blood glucose and serum cholesterol,but significantly inhibited the expression of NF-κB and lowered urinary protein excretion.Conclusion: Fluvastatin could protect the kidneys of diabetic rats probably through inhibiting the overexpression of NF-κB,independent of cholesterol-lowering effects.

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Available abstract

Objective: To study the protective effects of fluvastatin on the kidneys of diabetic rats.Methods: The models of diabetic rats were induced by streptozotocin.SD rats were randomly divided into three groups as control group,diabetic group and fluvastatin treated group.After four weeks,blood glucose,serum cholesterol and urinary protein were measured respectively.The expression of NF-κB in the glomerulus was determined by immunohistochemical staining.Results: Fluvastatin did not influence blood glucose and serum cholesterol,but significantly inhibited the expression of NF-κB and lowered urinary protein excretion.Conclusion: Fluvastatin could protect the kidneys of diabetic rats probably through inhibiting the overexpression of NF-κB,independent of cholesterol-lowering effects.

Key concepts: Fluvastatin, Endocrinology, Internal medicine, Streptozotocin, Kidney, Medicine, Diabetes mellitus, Diabetic nephropathy

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