1999•Zhonghua shenzangbing zazhiRequires access
Effect of fluvastatin on renal transforming growth factor 1 in diabetic rats
Wen Hui
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Abstract
Objective To investigate the effect of fluvastatin on renal transforming growth
factor 1(TGF1) in diabetes rats. Methods The following groups of rats were studied: normal
control ratsstreptozotocin diabetic rats and diabetic rats treated with
fluvastatin(2mgkg-1d-1).Plasma glucose, serum cholesterol, triglyceride and creatinine, urinary
albumin as well as profile of kidney hypertrophy were observed after 2,8 weeks of treatment,
while TGF1 mRNA expression of kidney contex was assessed by Northern blot
analysis.TGF1,fibronectin and collagen protein expression were measured by
immunohistological staining. Results Serum cholesterol,urinary albumin excretion(P001) and
kidney hypertrophy index(P005)in diabetic rats of fluvastatin treated group were significantly
lower than diabetic untreated rats.Compared to control group there was a significant increase in
mRNA and protein expression of TGF1 in association with increase of protien expression of
fibronectin and collagen in diabetes rats(P001).The mRNA expression of TGF1(P001) as well
as the protein expression of TGF1fibronectin and collagen (P005)in fluvastatin group were
much lower than diabetic untreated group. Conclusion Fluvastatin has some renal protective
effect on diabetes rats, partly through downregulating TGF1 expression and reducing deposition
of glomerular ECM.