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HMX: Acute Toxicity Tests in Laboratory Animals.

Jennifer A. Cuthbert, K J D'Arcy-Burt, Sally Carr

Abstract

The US Army requires information on the acute toxicity potential of Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) by oral, dermal and intravenous jroutes. In addition data on the acute skin and eye irritancy and skin sensitisation potentials of HMX are required. This report gives details of the following tests performed on HMX to meet these requirements. Acute Oral Toxicity (LD50) Test in Rats. Acute Oral Toxicity (LD50) Test in Mice. Acute Oral Toxicity in Rabbits (Dose Ranging). Acute Dermal Toxicity (LD50) in Rats. Acute Dermal Toxicity (LD50) in Rabbits. Intravenous Toxicity (LD50) in Rats. Intravenous Toxicity in Rabbits (Dose Ranging). Primary Skin Irritation Test in Rabbits. Eye Irritation (HMX 60% w/w in distilled water) in Rabbits. Eye Irritation (dried HMX) in Rabbits. Allergenic Potential in Guinea Pigs (Magnusson-Kligman Maximisation Test).

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Key concepts: Acute toxicity, Toxicity, Median lethal dose, Irritation, Skin irritation, Eye irritation, Medicine, Pharmacology