2006•PubMedRequires access

[Determination of diltiazem hydrochloride injection by high-performance liquid chromatography].

Tang Ling, Ting Zhang, Xinzhong Li

Abstract

OBJECTIVE: To establish an high-performance liquid chromatography (HPLC) method for the determination of diltiazem hydrochloride injection. METHODS: The assay was conducted on a NUCLEODUR C18 column with buffer solution (pH6.2)-acetonitrile-methanol (40:30:30) as the mobile phase and the detection wavelength was 240 nm. RESULTS: Diltiazem hydrochloride and relevant substances could be separated under the condition. The linear concentration range of diltiazem hydrochloride was 4 - 200mg/L with the recovery of 100.22% (RSD = 0.37%). CONCLUSION: The method may be used for the determination of diltiazem hydrochloride injection.

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Available abstract

Key concepts: Diltiazem hydrochloride, Diltiazem, Chromatography, High-performance liquid chromatography, Chemistry, Hydrochloride, Acetonitrile, Linear range