2003•Chinese Journal of PharmaceuticalsRequires access

Determination of Diltiazem Hydrochloride for Injection by HPLC

Lu Wang

Abstract

A HPLC method for the determination of diltiazem hydrochloride for injection and its related substances was presented. Diamonsil C18 column was used, with mobile phase of 0.1 mol/L sodium acetate buffer solution (pH6.2)-methanol-acetonitrile (5∶6∶6) and at detection wavelength of 236 nm. The detection limit was 0.2 ng. The linear range was 6～14 μg/ml, and average recovery was 100.2% with RSD of 0.52%.

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Key concepts: Chemistry, Chromatography, High-performance liquid chromatography, Diltiazem hydrochloride, Detection limit, Acetonitrile, Methanol, Linear range