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[The study of vascular endothelial growth factor in nasopharyngeal carcinoma patients before and after radiotherapy].

Yemin Liang, Cheng Yf, Huizhong Liu, Lina Hu

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Abstract

OBJECTIVE: The purpose of this study was to determine the serum vascular endothelial growth factor (VEGF) level before and after radiotherapy in the nasopharyngeal carcinoma. METHOD: In this study we used the methods of ELISA to test the serum VEGF level of 66 cases which including 46 cases of nasopharyngeal carcinoma and 20 cases of healthy controls. RESULT: The serum VEGF levels in nasopharyngeal carcinoma patients were significantly higher than those of healthy controls (P < 0.01). The serum levels of VEGF were significantly reduced at the end of radiotherapy (P < 0.01). The recurrence or metastasis rate was significantly higher in cases with > 150 ng/L VEGF level than those with < 150 ng/L. CONCLUSION: VEGF plays an important role in the growth and prognosis of nasopharyngeal carcinoma.

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What this paper is about

OBJECTIVE: The purpose of this study was to determine the serum vascular endothelial growth factor (VEGF) level before and after radiotherapy in the nasopharyngeal carcinoma. METHOD: In this study we used the methods of ELISA to test the serum VEGF level of 66 cases which including 46 cases of nasopharyngeal carcinoma and 20 cases of healthy controls. RESULT: The serum VEGF levels in nasopharyngeal carcinoma patients were significantly higher than those of healthy controls (P < 0.01). The serum levels of VEGF were significantly reduced at the end of radiotherapy (P < 0.01). The recurrence or metastasis rate was significantly higher in cases with > 150 ng/L VEGF level than those with < 150 ng/L. CONCLUSION: VEGF plays an important role in the growth and prognosis of nasopharyngeal carcinoma.

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Available abstract

OBJECTIVE: The purpose of this study was to determine the serum vascular endothelial growth factor (VEGF) level before and after radiotherapy in the nasopharyngeal carcinoma. METHOD: In this study we used the methods of ELISA to test the serum VEGF level of 66 cases which including 46 cases of nasopharyngeal carcinoma and 20 cases of healthy controls. RESULT: The serum VEGF levels in nasopharyngeal carcinoma patients were significantly higher than those of healthy controls (P < 0.01). The serum levels of VEGF were significantly reduced at the end of radiotherapy (P < 0.01). The recurrence or metastasis rate was significantly higher in cases with > 150 ng/L VEGF level than those with < 150 ng/L. CONCLUSION: VEGF plays an important role in the growth and prognosis of nasopharyngeal carcinoma.

Key concepts: Nasopharyngeal carcinoma, Medicine, Vascular endothelial growth factor, Radiation therapy, VEGF receptors, Internal medicine, Carcinoma, Gastroenterology

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[The study of vascular endothelial growth factor in nasopharyngeal carcinoma patients before and after radiotherapy]. — Research Paper | ScholarLens