Clinical Significance of Serum Vascular Endothelial Growth Factor(VEGF) in Nasopharyngeal Carcinoma

Objective To analyse the clinical significance of the serum VEGF in nasopharyngeal carcinoma(NPC).Methods The serum VEGF was measured by enzyme-linked immunosorbent assay(ELISA) in 40 healthy controls and 140 patients with NPC(63 untreated cases,41 cases with complete remission(CR) and 36 recurrent cases).Results The serum VEGF(ng/L) was (296.5±183.6),(278.7±169.6) and (369.3±315.6) in untreated cases,cases with CR and recurrent cases,respectively,showing a markedly higher level than that in control group(180.9±147.7)ng/L,P0.01,P0.05 and P0.01).The serum VEGF tended to increase with the development of tumor,especially when the distant metastasis happened.Furthermore,patients with high level of serum VEGF had a high risk of recurrence and metastasis.Conclusion The serum VEGF increases in patients with NPC.High VEGF level has a close relationship with the invasion of the tumor.