Correlation between nasopharyngeal carcinoma and the expression of VEGF protein in nasopharyngeal carcinoma

Objective:To investigate the expression of VEGF protein in nasopharyngeal carcinoma and nasopharyngeal mucosa tissue of chronic inflammation.Methods:Immunohistochemistry was used to determinate the expression of VEGF protein in tissue in 105 nasopharyngeal carcinoma patients,contrasted with 10 cases of normal nasopharyngeal tissue.All the patients had been received radical radiotherapy first.Followed up from 5 to 7 years,the rate of following up was 95%.Data was analyzed by SPSS version 13.0 software.Results:The positive expression of VEGF protein in nasopharyngeal carcinoma was 76%,which have statistical significance between carcinoma group and normal tissue group.Intensity of the expression of VEGF protein is related to lymph nodes metastasis,tumor stage,cranial nerve palsy,basalis encroachment(P 0.05) and not related to gender,age,encroachment in front or back of the belemnoid,VCA-IgA.Patients with negative expression of VEGF protein had better 5 years survival rate than positive expression,low expression had better 5 years survival rate than high expression.Cox regression indicated that the expression of VEGF protein was not evidently associated with the survival of the patients with nasopharyngeal carcinoma(P 0.05).Conclusion:The abnormal expression of VEGF plays a certain role in occurrence and development of nasopharyngeal carcinoma.