2000•PubMedRequires access
[The expression of P16 and Rb proteins in 106 cases of lung cancer].
Jian Qin, G-D Chen, X Wang
Open publisher page 3 citations
Abstract
OBJECTIVE: To observe the relationship between the expression of P16 and Rb proteins and the proliferation of lung cancer cells. METHODS: The expressions of P16 and Rb proteins were measured in 66 cases of NSCLC and 40 cases of SCLC by means of immunohistochemistry technique. RESULTS: The inverse correlation of Rb and P16 proteins expression was confirmed in 66 cases of NSCLC (chi 2 = 10.52, P < 0.01). No relationship between the expression of P16 and differentiation, stage, lymph node metastasis or pathological type was found (P > 0.05). There was no correlation between the expression of Rb and differentiation, stage, lymph node metastasis or pathological pattern (P > 0.05). The frequency of the loss of Rb protein expression in SCLC (78%) was significantly higher than in NSCLC (21%, chi 2 = 32.3, P < 0.01). CONCLUSIONS: Loss of Rb protein expression in SCLC may be an important marker of the diagnosis of SCLC. The expression of P16 adversely correlates with that of Rb. This study provides strong confirmation about that there might be a negative feedback between P16 and Rb in phase G1.