Expression of HIF-2α in Non Small Cell Lung Cancer Tissues and its Significance

Objective To observe the expression of HIF-2α in NSCLC and analyze its relationship with tumor biological feature.Methods The expression of HIF-2α in NSCLC tissues was evaluated by immunohistochemical method.Results The value of IOD of HIF-2α expression in NSCLC significantly higher than that in normal lung tissues(P0.05),HIF-2α expression is related to tumor lymph node metastasis and clinical stage,There is significant difference between group with lymph node metastasis and group without lymph node metastasis(P0.05),There is also significant difference among the HIF-2α expression during clinical stage of Ⅰ,Ⅱ,Ⅲ and Ⅳ(P0.05).HIF-2α expression has no obvious correlation with sex,age,size of tumor,differentiation degree,and pathological types (P0.05),but it is closely related to TNM stage and lymph node metastasis.Conclusion HIF-2α expression has close relationship with the invasive proceeding of NSCLC.