Significance of S100A4 and MMP-2 Expression in Oral Squamous Cell

Objective: To evaluate the clinical significance on the expression of S100A4 and MMP-2 in oral squanous cell carcinoma(OSCC).Methods: In 40 pathological diagnosed OSCC cases,S100A4 and MMP-2 were detected by immunohistochemical SP method.Normal oral mucosa was used as control.Result: ①Expression intensity of S100A4 in OSCC was not obviously related with the age,gender,tumor size,TNM clinical stage and pathological grade(P0.05). But expression rate of S100A4 in OSCC was positively correlated with lymph node metastasis(P0.05).② Expression of MMP-2 was not obviously related with the age,gender,tumor size and pathological grade(P0.05).The expression rate of MMP-2 in OSCC was positively correlated with lymph node metastasis(P0.05).In OSCC,protein expression of S100A4 and MMP-2 were positively coreelated.Conclusion: These genes and protein products may be served as a potential diagnostic targets in tumor metastasis.