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[Determination of oxymatrine content and its related substances in oxymatrine capsule by HPLC].

Wen‐Wei Qiu, Shujuan Jian, Huikang Gong

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Abstract

OBJECTIVE: To determine oxymatrine content and its related substances in oxymatrine capsule. METHODS: A HPLC method was adopted. C18 column was used. The mobile phase consisted of phosphate buffer solution-methanol (85:15). The UV detective wavelength was 210 nm. RESULTS: The calibration curve of oxymatrine was linear in the range of 6.952 - 20.856 microg/ml (r = 0.9999). The calibration curve of N-oxysophocarpine was linear in the range of 0.1837 - 0.5510 microg/ml (r = 0.9997). CONCLUSIONS: The method is simple, rapid and accurate.

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What this paper is about

OBJECTIVE: To determine oxymatrine content and its related substances in oxymatrine capsule. METHODS: A HPLC method was adopted. C18 column was used. The mobile phase consisted of phosphate buffer solution-methanol (85:15). The UV detective wavelength was 210 nm. RESULTS: The calibration curve of oxymatrine was linear in the range of 6.952 - 20.856 microg/ml (r = 0.9999). The calibration curve of N-oxysophocarpine was linear in the range of 0.1837 - 0.5510 microg/ml (r = 0.9997). CONCLUSIONS: The method is simple, rapid and accurate.

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Available abstract

OBJECTIVE: To determine oxymatrine content and its related substances in oxymatrine capsule. METHODS: A HPLC method was adopted. C18 column was used. The mobile phase consisted of phosphate buffer solution-methanol (85:15). The UV detective wavelength was 210 nm. RESULTS: The calibration curve of oxymatrine was linear in the range of 6.952 - 20.856 microg/ml (r = 0.9999). The calibration curve of N-oxysophocarpine was linear in the range of 0.1837 - 0.5510 microg/ml (r = 0.9997). CONCLUSIONS: The method is simple, rapid and accurate.

Key concepts: Oxymatrine, Calibration curve, Chromatography, Capsule, High-performance liquid chromatography, Phosphate buffered saline, Linear range, Chemistry

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