Discussion on the Relationship Between Nocturnal Acid Breakthrough and Esophagcal Acid Exposnre of Gastroesophageal Reflux Disease

Objective To discuss the relationship between nocturnal acid breakthrough(NAB)and esophageal acid exposure in patients with gastroesophageal reflux disease(GERD).Methods 45 cases of GERD patients were divided into two groups at random,including experimental group(24 cases) and control group(21 cases).Both of the two groups were given sodium rabeprazole 10 mg in the morning and the evening respectively,and experimental group(24 cases) was also given ranitidine 150 mg at bedtime,7 days as a course.24 h monitor of esophageal and gastric pH and reflux disease questionnaire(RDQ) scores were compared before and after treatment.Results The rate of NAB in experimental group was 20.83%,and the control group's was 57.14%,the difference was marked(P0.05).There was no significant difference in the median time percentage of esophageal pH4 at night and RDQ scores between the two groups before and after treatment(P0.05).Conclusion The control of esophageal acid exposure and gastroesophageal reflux symptoms may not relay on NAB remission,but depend on the improvement of esophageal motion abnormality to a great degree.