Correlation of Helicobacter pylori infection and gastroesophageal reflux disease relevance of nocturnal acid breakthrough

Objective To investigate the correlation of Helicobacter pylori infection and gastroesophageal reflux disease nocturnal gastric acid breakthrough. Methods A hospital in June 2012 ~ Jane 2013 treated patients with gastroesophageal flow method for the study 100 cases were randomly divided into control and experimental groups,each group of 50 patients. Control group of patients using omeprazole treatment,patients in the control group,the experimental group on the basis of additional services bismuth potassium citrate oral solution,oral amoxicillin and metronidazole,two groups of patients were 10 days treatment. Check the patient 22: 00 ~ 8: 00 the next day during the nocturnal gastric acid breakthrough in the situation,and in patients with RDQ score. Results In the control group,the incidence of nocturnal acid breakthrough was 22. 0%,significantly lower than 52. 0% of the experimental group,the difference was statistically significant( P 0. 05); The control group and the experimental group were treated ROD scores were significantly decreased,and before treatment,the difference was statistically significant( P 0. 05); Patients before and after treatment between the two groups showed no significant difference( P 0. 05). Conclusion The occurrence of symptoms of gastroesophageal reflux disease does not depend nocturnal acid breakthrough,Helicobacter pylori is a protective factor for gastroesophageal reflux disease,helicobacter pylori clearance will increase the occurrence of nocturnal acid breakthrough.