2013•Zhongguo yaofangRequires access
Clinical Observation of Different Dose of Atorvastatin Versus Simvastatin in the Treatment of Coronary Heart Disease in Elderly Patients with Hyperlipidemia
Fang Ca
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Abstract
OBJECTIVE:To observe clinical efficacy and safety of different dose of atorvastatin vs.simvastalin in the treatment of coronary heart disease in elderly patients with hyperlipidemia.METHODS:150 elderly patients with coronary heart disease complicating with hyperlipidemia were randomly divided into observation group Ⅰ,observation group Ⅱ and control group with 50 cases in each group.Observation group Ⅰ was given atorvastatin 10 mg/d once a day;observation group Ⅱ was given atorvastatin 20 mg/d once a day half hour after a meal;control group was given simvastatin 20 mg/d half hour after supper.A treatment course lasted for 8 weeks,and the patients received one to 3 courses according to disease condition.Changes of blood lipid,total effective rate and the occurrence of ADR were compared between before treatment and 4 and 8 weeks after treatment.RESULTS:After 4 weeks of treatment,blood lipid levels of observation group Ⅰ,observation group Ⅱ and control group were decreased significantly than before(P0.05);there was no statistical significance among 3 groups(P0.05).After 8 weeks of treatment,blood lipid levels of 3 group were decreased significantly(P0.05),the level of TC,TG,LDL-C of observation group Ⅱ was significantly lower than that of observation group Ⅰ and control group(P0.05),and there was no statistical significance of the blood lipid in observation group Ⅰ and control group(P0.05).After 8 weeks,the toatal effective rate of observation group Ⅱ was much higher than that of observation group Ⅰ and control group,there was no statistical significance among 3 groups.There was no statistical significance in the incidence of ADR among 3 groups(P0.05).CONCLUSIONS:Therapeutic efficacy of atorvastatin is better than that of simvastatin in the treatment of senile coronary heart disease complicating with hyperlipemia,and have obvious dependence on dose.The higher dose is,the more obvious effect is;the ADR has no change and the clinical effect is safe and stable.