Clinical Study of the Atorvastatin Pharmacological Effects and the Efficacy of Control Lipid Levels

Objective To summarize the pharmacological effects of atorvastatin,explore atorvastatin treatment efficacy and mechanism of coronary heart disease hyperlipidemia.Methods 120 patients were randomly divided into the observation group and the control group,the two groups were given the basis treatment,in the same period,the observation group plus the atorvastatin 20 mg/d,1 time/d.Over the same period,the control group plus simvastatin 20 mg/d,1/d,the course was 4 weeks.Determine the lipid levels and BNP concentration in the two groups of patients before and after treatment.Results After treatment,compared with before treatment,the TC,TG and LDL-C levels of the two groups were significantly lower,HDL-C was significantly higher,observation group were especially significantly(P0.05);After treatment,the differences of the TC,TG,LDL-C and HDL-C levels between the observation group and the control group were significant(P0.05).BNP levels significantly reduced after treatment in both groups,the difference was statistically significant(P0.05),compared with before treatment,and the BNP in the observation group decreased significantly than in the control group(P0.05).The incidence of adverse reactions in the observation group was 2/60(3.33%),3/60(5%)in the control group,the incidence of adverse reactions was no significant difference between the two groups(P 0.05).Conclusion Atorvastatin can be able to reduce blood lipid levels which is a safe and effective drug to treat coronary heart disease combined hyperlipidemia.