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Determination of Chlorgenic acid in Injection of Folium Isatidis Mixture by HPLC

Jing Wu

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Abstract

Objective To develop a method for determination content of Chlorgenic acid in injection of Folium isatidis mixture by HPLC.Method HPLC was used with C_(18) column,acetonitrile-0.4%phosphoric acid(13∶87) as mobil phase and detection wavelength was 327 nm,.flow rate was 1.0 mL·min~(-1)Result The linearity was obtained over the range of 0.02~0.7 mg·mL~(-1)(r=0.999 9).The average recovery was 99.6%,RSD was 0.21%(n=5).Conclusion This method is simple,rapid,accurate and can be used for the control quality of injection of Folium isatidis mixture.

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Objective To develop a method for determination content of Chlorgenic acid in injection of Folium isatidis mixture by HPLC.Method HPLC was used with C_(18) column,acetonitrile-0.4%phosphoric acid(13∶87) as mobil phase and detection wavelength was 327 nm,.flow rate was 1.0 mL·min~(-1)Result The linearity was obtained over the range of 0.02~0.7 mg·mL~(-1)(r=0.999 9).The average recovery was 99.6%,RSD was 0.21%(n=5).Conclusion This method is simple,rapid,accurate and can be used for the control quality of injection of Folium isatidis mixture.

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Available abstract

Objective To develop a method for determination content of Chlorgenic acid in injection of Folium isatidis mixture by HPLC.Method HPLC was used with C_(18) column,acetonitrile-0.4%phosphoric acid(13∶87) as mobil phase and detection wavelength was 327 nm,.flow rate was 1.0 mL·min~(-1)Result The linearity was obtained over the range of 0.02~0.7 mg·mL~(-1)(r=0.999 9).The average recovery was 99.6%,RSD was 0.21%(n=5).Conclusion This method is simple,rapid,accurate and can be used for the control quality of injection of Folium isatidis mixture.

Key concepts: Folium of Descartes, Chromatography, Phosphoric acid, Chemistry, High-performance liquid chromatography, Acetonitrile, Recovery rate, Organic chemistry

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