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2008•Central South PharmacyRequires access

Determination of icariin in kangguzengsheng pills by HPLC

Jiang Gui-ping

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Abstract

Objective To develop an HPLC method for the determination of icariin in Kangguzengsheng pills.Methods A C18 column(4.6 mm×200 mm,5 μm),and a mobile phase composed of acetonitrile-water(26∶74)were adopted.The flow rate was 1.0 mL·min-1 and wave length was 270 nm.Results The linear range was 0.040 4～0.504 μg,r=0.999 98.The recovery of paeoniflorin was 98.4% with RSD=0.7%(n=6).Conclusion The determination method is simple and accurate,and can be used for the quality control of Kangguzengsheng pills.

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What this paper is about

Objective To develop an HPLC method for the determination of icariin in Kangguzengsheng pills.Methods A C18 column(4.6 mm×200 mm,5 μm),and a mobile phase composed of acetonitrile-water(26∶74)were adopted.The flow rate was 1.0 mL·min-1 and wave length was 270 nm.Results The linear range was 0.040 4～0.504 μg,r=0.999 98.The recovery of paeoniflorin was 98.4% with RSD=0.7%(n=6).Conclusion The determination method is simple and accurate,and can be used for the quality control of Kangguzengsheng pills.

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Available abstract

Objective To develop an HPLC method for the determination of icariin in Kangguzengsheng pills.Methods A C18 column(4.6 mm×200 mm,5 μm),and a mobile phase composed of acetonitrile-water(26∶74)were adopted.The flow rate was 1.0 mL·min-1 and wave length was 270 nm.Results The linear range was 0.040 4～0.504 μg,r=0.999 98.The recovery of paeoniflorin was 98.4% with RSD=0.7%(n=6).Conclusion The determination method is simple and accurate,and can be used for the quality control of Kangguzengsheng pills.

Key concepts: Icariin, Paeoniflorin, Chromatography, High-performance liquid chromatography, Linear range, Chemistry, Content determination, Medicine

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