Influence of montelukast combined with salmeterol fluticasone on interleukin-4( IL-4) and interferon-γ( IFN-γ) levels of patients with cough variant asthma

Objective To discuss the influence of montelukast combined with salmeterol fluticasone on interleukin-4( IL-4) and interferon-γ( IFN-γ) levels of patients with cough variant asthma. Methods 74 patients with cough variant asthma in our hospital were selected and divided into experimental group and control group at random. The patients of the two groups were given the inhibition of salmeterol fluticasone one suck per time,tw ice daily. The patients of the experimental group were given 10 mg montelukast dulcets additionally once daily for 12 weeks. The changes of serum IL-4 and IFN-γ levels of the two groups were observed before and after treatment,and the clinical curative effect and security were observed as well. Results After 12 weeks' treatment,the serum IL-4 level of patients of the two group declined obviously than before treatment,while the IFN-γ level rose obviously than before treatment(P 0. 01 or P 0. 05),and declining or rising rate of experimental group was obviously higher than those of control group( P 0. 05). Meanwhile,the total clinical efficiency of experimental group was much higher than that of control group( χ2= 4. 16,P 0. 05). 3 and 6 cases of adverse reactions in control group and experimental group with light symptom without serious drug adverse reaction( DAR) during the medical treatment respectively. After comparing the occurrence rates of adverse reactions in the two groups,no obvious statistical difference appeared during the medical treatment( χ2= 0. 51,P 0. 05). Conclusion Montelukast combined with salmeterol fluticasone has reliable curative effect on cough variant asthma with high security,which has close effect on reducing serum IL-4 level,improving serum IFN-γ level,and correcting Th1 / Th2 cytokine dysequilibrium.