ScholarLens Back to search
2004•Chinese Journal of MisdiagnosticsRequires access

Effects of Simvastatin on Serum Matrix Metalloproteinases-9 and C-reactive Protein Levels in Patients of Coronary Heart Disease

Jing Ge

Open publisher page 0 citations

Abstract

Objective:To observe the effects of simvastatin on matrix mata lloproteiases 9(MMP 9),c reactive protein(CRP) level in patients with stable an gina pectoris(SAP) and acute coronary syndrome(ACS). Methods:Thirty SAP and th irty ACS patients were randomly divided into either the simvastatin group or the control group. The levels of MMP 9 and CRP before and after treatment were detected.Results:After treatment with simvastatin,the levels of MMP 9 and CRP in both two groups significantly decreased (P0. 001).Conclusion:Simvastatin decreased level of inflammatory factors in the patients of SAP and ACS, so it could benefit to atherosclerotic plaque stabilization.

About this research paper

What this paper is about

Objective:To observe the effects of simvastatin on matrix mata lloproteiases 9(MMP 9),c reactive protein(CRP) level in patients with stable an gina pectoris(SAP) and acute coronary syndrome(ACS). Methods:Thirty SAP and th irty ACS patients were randomly divided into either the simvastatin group or the control group. The levels of MMP 9 and CRP before and after treatment were detected.Results:After treatment with simvastatin,the levels of MMP 9 and CRP in both two groups significantly decreased (P0. 001).Conclusion:Simvastatin decreased level of inflammatory factors in the patients of SAP and ACS, so it could benefit to atherosclerotic plaque stabilization.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To observe the effects of simvastatin on matrix mata lloproteiases 9(MMP 9),c reactive protein(CRP) level in patients with stable an gina pectoris(SAP) and acute coronary syndrome(ACS). Methods:Thirty SAP and th irty ACS patients were randomly divided into either the simvastatin group or the control group. The levels of MMP 9 and CRP before and after treatment were detected.Results:After treatment with simvastatin,the levels of MMP 9 and CRP in both two groups significantly decreased (P0. 001).Conclusion:Simvastatin decreased level of inflammatory factors in the patients of SAP and ACS, so it could benefit to atherosclerotic plaque stabilization.

Key concepts: Simvastatin, Medicine, C-reactive protein, Acute coronary syndrome, Stable angina, Internal medicine, Matrix metalloproteinase, Coronary heart disease

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of Simvastatin on Serum Matrix Metalloproteinases-9 and C-reactive Protein Levels in Patients of Coronary Heart Disease — Research Paper | ScholarLens