Effect of simvastatin on inflammatory factor serum levels in patients with acute coronary syndrome after percutaneous coronary intervention

Objectives To observe effects of simvastatin on plasma levels solubility intercellular adhesion molecule-1(sICAM-1),matrix metalloproteinase-9(MMP-9) and C-reactive profein(CRP) in patients of acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI) and clinical significance.Methods Patients with ACS after PCI were randomly assigned into three groups: one group treated with simvastatin 40 mg/d,another group treated with simvastatin 20 mg/d,while the control group without treated with simvastatin.Before and after the four week treatment,the plasma levels of sICAM-1、MMP-9 and CRP were detected.Results After treatments of simvastatin 20 mg or 40 mg,all patients reduced the levels of sICAM-1,MMP-9 and CRP to the levels of the control group;The levels of sICAM-1,MMP-9 and CRP markedly reduced in simvastatin 40 mg group.Conclusions Treatments with high-dose simvastatin(40 mg)for four weeks could reduce the levels of sICAM-1,MMP-9 and CRP,and improve the function of vascular endothelium,which may promote the stabilization of atherosclerotic plaque.