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The effect of simvastatin on C reactive protein and plasma lipid in early stage of the acute coronary syndrome

AN Shu-xia

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Abstract

Objective To observe the effct of simvastatin on C reactive protein(CRP) and plasma lipid in early stage of the acute coronary syndrome.Methods 70 patients with acute coronary syndrome were divided randomly into treatment group(simvastatin 10mg/d,n=36) and control group(no lipid-lowering agents,n=34).The level of CRP and plasma lipid before and after treatment were detected.Results Levels of CRP,TC and LDL-C significantly decreased by 35%,30% and 40% in the treatment group.The difference between the control and treatment group was significant(P0.05).There were lower rates of acute myocardial infarction and re-hospitalization in treatment-group than those in control-group.Conclusion Simvastatin can decrease the levels of plasma lipid and inflammatory foctors in early stage of the acute coronary syndrome,so it may benefit atherosclerotic plaque stabilization.

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What this paper is about

Objective To observe the effct of simvastatin on C reactive protein(CRP) and plasma lipid in early stage of the acute coronary syndrome.Methods 70 patients with acute coronary syndrome were divided randomly into treatment group(simvastatin 10mg/d,n=36) and control group(no lipid-lowering agents,n=34).The level of CRP and plasma lipid before and after treatment were detected.Results Levels of CRP,TC and LDL-C significantly decreased by 35%,30% and 40% in the treatment group.The difference between the control and treatment group was significant(P0.05).There were lower rates of acute myocardial infarction and re-hospitalization in treatment-group than those in control-group.Conclusion Simvastatin can decrease the levels of plasma lipid and inflammatory foctors in early stage of the acute coronary syndrome,so it may benefit atherosclerotic plaque stabilization.

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Available abstract

Objective To observe the effct of simvastatin on C reactive protein(CRP) and plasma lipid in early stage of the acute coronary syndrome.Methods 70 patients with acute coronary syndrome were divided randomly into treatment group(simvastatin 10mg/d,n=36) and control group(no lipid-lowering agents,n=34).The level of CRP and plasma lipid before and after treatment were detected.Results Levels of CRP,TC and LDL-C significantly decreased by 35%,30% and 40% in the treatment group.The difference between the control and treatment group was significant(P0.05).There were lower rates of acute myocardial infarction and re-hospitalization in treatment-group than those in control-group.Conclusion Simvastatin can decrease the levels of plasma lipid and inflammatory foctors in early stage of the acute coronary syndrome,so it may benefit atherosclerotic plaque stabilization.

Key concepts: Simvastatin, Medicine, Acute coronary syndrome, Internal medicine, Myocardial infarction, C-reactive protein, Plasma levels, Lipid profile

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The effect of simvastatin on C reactive protein and plasma lipid in early stage of the acute coronary syndrome — Research Paper | ScholarLens