Analysis of the Relationship between Anemia and Heart Function in Patients with Chronic Heart Failure Caused by Coronary Heart Disease

Objective: To investigate the relationship between anemia and heart function in hospitalized patients with chronic heart failure caused by coronary heart disease. Methods: Patients with chronic heart failure caused by coronary heart disease, who were hospitalized in the Second Hospital of Tianjin Medical University between December 2005 and January 2007, were included in this study. Based on hemoglobin (Hb) levels, patients were divided into anemia group and non-anemia group. The relationship of the incidence data and the cardiac functions was retrospectively analyzed between two groups. Results: There were 1 816 patients in this study, and the proportion of male and female patients with anemia were 16.34% (151/925) and 17.28% (154/891) respectively. The average age was higher in patients of anemia group than that of the non-anemia group (t = 6.823, P 0.01). The proportion of ≥60 years of age was higher in patients of anemia group than that of non-anemia group (χ2 =13.312,P 0.01). With the progression of the heart function classification, the value of hemoglobin had a lower gradually trend, and the proportion of anemia had a higher gradually trend. There was a negative correlation between the heart function classification and the value of hemoglobin ( r = -0.192,P 0.05). The value of left ventricular end diastolic diameter (LVEDD) was higher, but interventricular septum thickness (IVS) was lower, in patients of anemia group than that of non-anemia group. The majority proportion of left ventricular ejection fraction (LVEF) was ≤0.45 in patients of anemia group. The proportion of E/A≤1 was significantly higher than E/A1 in patients of two groups. Conclusion: The chronic heart failure should be treated with the correction of anemia at the same time, which could significantly improve the prognosis of patients with chronic heart failure.