Effects of Different Doses of Atorvastatin Calcium on Endothelial Function in Hypertension Patients with Normal Blood Lipid

OBJECTIVE:To observe the effects of different doses of atorvastatin calcium on endothelial function in hypertension patients with normal blood lipid.METHODS:98 hypertension patients with normal blood lipids were randomly divided into group A and group B. Other 30 patients were included in healthy control group. 2 groups were give medicines according to previous anti-hypertension plan. Group A was given atorvastatin calcium 10 mg,and group B was treated with atorvastatin calcium 20 mg. Treatment course of both groups lasted for 4 weeks. The blood fat vasodilation(FMD)and endothelium non-dependent vasodilation(EID)were observed in 2 groups before and after treatment,and compared with the healthy control group.RESULTS:There was no statistical significance in the level of blood fat of 2 groups in same group,and the level between 2 groups before and after treatment(P0.05). Before treatment,FMD and EID of both groups were significantly lower than those of healthy control group. After treatment,FMD of both groups were significantly higher than before,and the improvement of FMD in group B was better than in group A;there were statistical significance(P0.05);there was no statistical significance in EID of 2 groups before and after treatment(P0.05). FMD and EID of 2 groups were significantly lower than those of healthy control group after treatment;there was statistical significance(P0.05). Adverse drug reactions were mild in two groups.CONCLUSIONS:Atorvastatin calcium has improved endothelial function in hypertension patients with normal blood lipid may be related to measurement.