Effects of atorvastatin administration on vascular endothelial function in patients of isolated systolic hypertension

Objective To investigate effects of atorvastatin administration on vascular endothelial function in patients of isolated systolic hypertension(ISH) with hyperlipidemia or without.Methods Sixty patients with ISH and hyperlipidemia were randomly divided into the atorvastatin 10mg group(Group A) and the 20mg group(Group B),and the other 30 ISH patients without hyperlipidemia were served as control.Blood pressure,LDL-C,TC,ET-1,nitric oxide(NO) and FMD level were measured before and 12 weeks after the treatment.Results LDL-C,TC,FMD,NO and ET1 had no significant difference between the two groups Group A and B before treatment,but compared with Group C they were significantly different.After 12 weeks,LDL-C and TG were significantly reduced in all three groups;NO and FMD were significantly increased;And ET-1 levels were significantly lower(P0.05).Univariate analysis suggested that the improvement of FMD,NO and ET-1 level were not correlated with the baseline of TC,LDL-C level and the decrease(P0.05),but the improvement of FMD had a close relation with the improvement of the serum ET-1 and NO level(P0.05).Conclusion Atorvastatin obvorsly improves vascular endothelial function of patients with ISH complicated with hyperlipidemia or without,and is independent of their lipid-lowering effect and in dose-dependent manner.