A Clinical Controlled Study of Medilac-S and Liuwei-Anxiao Capsules in Patients with Functional Constipation.

Objective To evaluate the efficacy and safety of Medilac-s and Liuwei-Anxiao capsules in patients with functional constipation.Methods Sixty patients diagnosed as functional constipation according to the RomeⅢcriteria were randomly divided into two groups and followed up for 4 weeks.A group (n=33)was given with 3 capsules of liuwei-anxiao and medilac-s 500mg,three times daily and B group(n=32)was given with 3 capsules liuwei-anxiao and medilac-s 500mg,three times daily.The bowel movement frequencies,stool property and constipation symptom scores were observed.Results Four weeks later,The bowel movement frequencies,the Bristol Stool Form Scale,the symptomatic scores have significant improvement in both groups compared with baseline.There was significant difference of efficiency in therapy group than that in control group(P0.05).Conclusion Medilac-s and Liuwei-Anxiao capsules are effective and safe for patients with chronic functional constipation.Combined with Bacillus subtilis and Enterococcus faecim could improve patients’stool description,clinical symptom..