2010•Rare & Special e-Zone (The Hong Kong University of Science and Technology)Requires access
Meta-analysis on efficacy and safety of quetiapine and haloperidol in treatment of schizophrenia
Fang Fang, Zhicheng Wang, Yan Yao, Bo Li, Ya Liu
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Abstract
Objective: To assess the efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia and the differences in adverse effects of them. Methods: Meta analysis on the 14 papers about efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia was performed, and the total effective rate, cure ratative, obvious effective rate and adverse effects were evaluated. Results: Circled digit 1 Haloperidol and quetiapine had similar total effective rate (P = 0.76); Circled digit 2 there was significant difference of curative rate between haloperidol and quetiapine in treatment of schizophrenia (P = 0. 04); Circled digit 3 Compared with haloperidol, quetiapine had a higher obvious effective rate (P = 0.006); Circled digit 4 the incidence rates of akathisia, myotonia, dry mouth etc in quetiapine group were lower than those in haloperidol group (P<0.05). Conclusion: Quetiapine is better than haloperidol on the cure rate and obvious effective rate in the treatment of schizophrenia. Further, quetiapine has less extrapyramidal reactions.