A clinical analysis between quetiapine and haloperidol in the treatment of schizophrenia

Objective:To compare the efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia.Methods:72 patients with schizophrenia by CCMD-3 were randomly allocated to two groups treated with quetiapine or haloperidol for 8 weeks.The Positive and Negative Syndrome Scale(PANSS) and Treatment Emergent Side effect Scale(TESS) were used to evaluate efficacy and adverse effect respectively.Results: The efficacy rates of quetiapine was 94.5%,and the significant efficacy rates was 91.7% after 8 weeks,without any significant difference between two groups(P0.05).However,the incidence rate of adverse effect is 38.89% and 75.00% respectively,significantly lower in quetiapine group(P0.01).Scores of cognitive function were significantly lower in quetiapine group than those in haloperdol group(P0.05).Conclusions: Quetiapine has a similar totam efficacy but fewer side effects compared with haloperidol,quetiapine may have a better effect on cognitive function than that of haloperidol.