2008•Laboratory Medicine and ClinicRequires access
Clinical significance of combined detection of serum tumor markers in the diagnosis and treatment of gastric cancer
Huang Fa-li
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Abstract
Objective To explore the clinical significance of combined detection of serum carcinoembryonic antigen(CEA)and CA724 in the diagnosis and treatment of gastric cancer.Methods Serum level of CEA in patients with gastric canner(n=58),gastritis(n=50)or gastric ulcer(n=50)was detected with radioimmunoassay(RIA).Serum CA724 was detected by using chemiluminescent immunoassay(CLIA).Results The levels and positive rate of serum CEA,CA724 in patients with gastric cancer were significantly higher than those in patients with gastritis or gastric ulcer(P0.05).The levels and positive rate of serum CEA,CA724 in patients with gastric cancer 3 mouths after operation were significantly lower than those of pre-operation gastric cancer patients(P0.05).The positive rate during pre-operation with combined detection of CEA and CA724 was more elevated than that by single marker detection.The serum level of CA724 kept increasing with TNM clinical stages.The serum contents of CEA and CA724 were significantly higher in relapsing patients than those of non-relapsing patients at one year after operation(P0.05).Conclusion Detection of serum CEA and CA724 is useful for the diagnosis,curative effect monitoring and prognosis evaluation of gastric cancer.Combined detection of serum CEA and CA724 can increase their clinical value.