2011•Journal of Jiangsu UniversityRequires access
Clinical significance of combined detection of CEA,CA19-9 and CA72-4 in patients with gastric cancer
Hui Qian
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Abstract
Objective: To investigate the clinical value of serum CEA、CA19-9、CA72-4 in patients with gastric cancer.Methods: The levels of serum CEA,CA19-9 and CA72-4 were measured in patients with gastric cancer,benign gastric diseases and normal control by an electrochemiluminescence method,the data were carried on statistics analysis.Results: The levels of serum CEA,CA19-9 and CA72-4 in patients with gastric cancer were significantly higher than in benign gastric disease patients and normal control,the difference was statistically significant(P0.01).The levels of serum CEA,CA19-9 and CA72-4 showed no significant difference among different differentiation groups of gastric cancer(P0.05),and between lymph node metastasis group and non-metastasis group(P0.05).ROC curve were applied in analysis of CEA,CA19-9 and CA72-4 in gastric cancer,the area under the curve were 0.694±0.051,0.651±0.053,0.703±0.049,respectively.Compared with benign gastric diseases and normal control,the difference was statistically significant(P0.01).Conclusion: Combined detection of the levels of serum CEA,CA19-9 and CA72-4 in patients with gastric cancer can improve the diagnostic sensitivity,and provide useful clinical information on the severity and prognosis in gastric cancer.