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2012•Acta Medicinae SinicaRequires access

Expression of E-Cadherin in type I endometrial carcinoma

Zhao Shi-mei

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Abstract

Objective: To investigate expression of epithelial cadherin protein-E(E-Cadherin) in type Ⅰ endometrial carcinoma and its significance.Methods: Immunohistochemical EnVision method was adopted to detect the E-Cadherin protein expression of 30 cases of proliferative phase endometrium;36 cases of simple hyperplasia of endometrium;50 cases of atypical hyperplasia endometrium and 55 cases of type Ⅰ endometrial carcinoma.Results: From the proliferative phase endometrium,simple hyperplasia of endometrium,atypical hyperplasia endometrium to type Ⅰ endometrial cancer,expression of normal E-cadherin decreased gradually,heterogeneous expression of E-cadherin gradually increased(P0.01).The expression of E-cadherin protein in endometrial carcinoma did not correlated with age and histological grade(P0.05).Conclusion: Expression of E-cadherin protein is associated with the development of type I endometrial carcinoma.

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What this paper is about

Objective: To investigate expression of epithelial cadherin protein-E(E-Cadherin) in type Ⅰ endometrial carcinoma and its significance.Methods: Immunohistochemical EnVision method was adopted to detect the E-Cadherin protein expression of 30 cases of proliferative phase endometrium;36 cases of simple hyperplasia of endometrium;50 cases of atypical hyperplasia endometrium and 55 cases of type Ⅰ endometrial carcinoma.Results: From the proliferative phase endometrium,simple hyperplasia of endometrium,atypical hyperplasia endometrium to type Ⅰ endometrial cancer,expression of normal E-cadherin decreased gradually,heterogeneous expression of E-cadherin gradually increased(P0.01).The expression of E-cadherin protein in endometrial carcinoma did not correlated with age and histological grade(P0.05).Conclusion: Expression of E-cadherin protein is associated with the development of type I endometrial carcinoma.

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Available abstract

Objective: To investigate expression of epithelial cadherin protein-E(E-Cadherin) in type Ⅰ endometrial carcinoma and its significance.Methods: Immunohistochemical EnVision method was adopted to detect the E-Cadherin protein expression of 30 cases of proliferative phase endometrium;36 cases of simple hyperplasia of endometrium;50 cases of atypical hyperplasia endometrium and 55 cases of type Ⅰ endometrial carcinoma.Results: From the proliferative phase endometrium,simple hyperplasia of endometrium,atypical hyperplasia endometrium to type Ⅰ endometrial cancer,expression of normal E-cadherin decreased gradually,heterogeneous expression of E-cadherin gradually increased(P0.01).The expression of E-cadherin protein in endometrial carcinoma did not correlated with age and histological grade(P0.05).Conclusion: Expression of E-cadherin protein is associated with the development of type I endometrial carcinoma.

Key concepts: Endometrium, Carcinoma, Atypical hyperplasia, Cadherin, Immunohistochemistry, Hyperplasia, Endometrial cancer, Endometrial hyperplasia

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