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Determination of Acetamidopyrrolidone in Compound Huonaosu Capsules by RP-HPLC

Chun Hua Zhao

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Abstract

Objective: To establish the determination method of acetamidopyrrolidone in Compound Huonaosu Capsules with RP HPLC. Methods: Kromasil C 18 column was used. The mobile phase was methanol water(10∶90) with 0.6ml·min -1 of flow rate, and the detection wavelength was at 230nm. Results: The linear range of acetamidopyrrolidone concentration was from 0.17 to 0.78mg·ml -1 and correlation coefficient was 0.9995. The average recovery of sample was 99.9% and RSD and 0.62%(n=5). Conclusion: The method is simple, accurate and reproducible. It can be used for determination of acetamidopyrrolidone Compound in Huonaosu Capsules.

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What this paper is about

Objective: To establish the determination method of acetamidopyrrolidone in Compound Huonaosu Capsules with RP HPLC. Methods: Kromasil C 18 column was used. The mobile phase was methanol water(10∶90) with 0.6ml·min -1 of flow rate, and the detection wavelength was at 230nm. Results: The linear range of acetamidopyrrolidone concentration was from 0.17 to 0.78mg·ml -1 and correlation coefficient was 0.9995. The average recovery of sample was 99.9% and RSD and 0.62%(n=5). Conclusion: The method is simple, accurate and reproducible. It can be used for determination of acetamidopyrrolidone Compound in Huonaosu Capsules.

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Available abstract

Objective: To establish the determination method of acetamidopyrrolidone in Compound Huonaosu Capsules with RP HPLC. Methods: Kromasil C 18 column was used. The mobile phase was methanol water(10∶90) with 0.6ml·min -1 of flow rate, and the detection wavelength was at 230nm. Results: The linear range of acetamidopyrrolidone concentration was from 0.17 to 0.78mg·ml -1 and correlation coefficient was 0.9995. The average recovery of sample was 99.9% and RSD and 0.62%(n=5). Conclusion: The method is simple, accurate and reproducible. It can be used for determination of acetamidopyrrolidone Compound in Huonaosu Capsules.

Key concepts: Chromatography, Correlation coefficient, Chemistry, High-performance liquid chromatography, Linear correlation, Linear relationship, Linear range, Coefficient of variation

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