Effects and Mechanism of Trimetazidine on Oxidative Stress in Rats with Chronic Heart Failure

Objective To investigate the effects of trimetazidine on the injury of oxidative stress in rats with chronic heart failure(CHF). Methods Male SD rats were randomly divided into blank control,model,low trimetazidine treated and high trimetazidine treated groups.Rats except for the blank control were abdominal aortic constricted.Four weeks later,echocardiography,real time PCR,serological and myocardial pathological examination were performed,SOD in myocardium was determined. Results Compared with the model rats,both LVPW and LVD of the rats in high dose of trimetazidine treated group were raised.The microscopic and electron microscopic examination showed that the myocardial injury in high dose of trimetazidine treated group were ameliorated compared with those in the model.The level of SOD showed significant difference among groups(P0.05). Conclusion Trimetazidine can improve antioxidance,pathological change and ultrastructure of myocardium and enhance the cardiac function in rats with heart failure.