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2004•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

Determination of Baicalin in Shengjijiedu Granule by HPLC

Lai Rong-sheng, Pan Jin-huo

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Abstract

Objective To establish a method for the determination of Baicalin content in Shengjijiedu Granule by HPLC.Method HPLC was performed to determine naringin content on C18 column.The mobile phase consisted of a mixture of CH3OH-H2O-H3PO4(50 ∶50 ∶0.2) and detection wavelength was at 280 nm.Result The linearity of baicalin was in the range of 0.015～0.121 μg (r=0.9999) and the average recovery rate was 100.98 %,RSD=0.84 %.Conclusion This method was simple,sensitive and accurate,and can be used for the quality control of Shengjijiedu granule.

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What this paper is about

Objective To establish a method for the determination of Baicalin content in Shengjijiedu Granule by HPLC.Method HPLC was performed to determine naringin content on C18 column.The mobile phase consisted of a mixture of CH3OH-H2O-H3PO4(50 ∶50 ∶0.2) and detection wavelength was at 280 nm.Result The linearity of baicalin was in the range of 0.015～0.121 μg (r=0.9999) and the average recovery rate was 100.98 %,RSD=0.84 %.Conclusion This method was simple,sensitive and accurate,and can be used for the quality control of Shengjijiedu granule.

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Available abstract

Objective To establish a method for the determination of Baicalin content in Shengjijiedu Granule by HPLC.Method HPLC was performed to determine naringin content on C18 column.The mobile phase consisted of a mixture of CH3OH-H2O-H3PO4(50 ∶50 ∶0.2) and detection wavelength was at 280 nm.Result The linearity of baicalin was in the range of 0.015～0.121 μg (r=0.9999) and the average recovery rate was 100.98 %,RSD=0.84 %.Conclusion This method was simple,sensitive and accurate,and can be used for the quality control of Shengjijiedu granule.

Key concepts: Baicalin, Chromatography, Granule (geology), High-performance liquid chromatography, Naringin, Chemistry, Content determination, Recovery rate

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