Synthesis of N-Ferrocenylformylglycine

Ferrocenylformyl chloride was synthesized by the acylation reaction of ferrocenecarboxylic acid.N-Ferrocenylformylglycine was prepared by treating ferrocenylformyl chloride with glycine in a mixed solvent of acetone-water.The optimum conditions for the reaction were: the molar ratio of ferrocenylformyl chloride and glycine was 1∶2,the pH of the solution was kept within 8～9 during the reaction,the reaction temperature was controlled at 20～25°C.After 3 h, the pH of the solution was adjusted to 1～2 by hydrochloric acid in order to transformed the sodium salt to the acid.The precipitate was collected by filtration under reduced pressure.The yield was 89.0%.The structure of the target compound was confirmed by elemental analysis,IR and()~1H NMR.