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2010•Medical Journal of CommunicationsRequires access

The expression and significance of PCNA in cervical cancer

Ji Eun Yun

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Abstract

Objective:To explore the singnificance of proliferating cell nuclear antigen(PCNA) expression in cervical cancer.Methods:Immunohistochemical SP method was opplied to determine the expression of PCNA in 64 cervical cancer tissues and 17 Cervical intraepithelial neoplasia(CIN) cervical tissues and 14 normal cervical tissues.The relationship between the expression and clinical pathology was analyzed.Results:The positive rate of PCNA in cervical cancer was singnificantly higher than that in CIN and normal cervical tissues(P0.05).The expression of PCNA in cervical cancer was associated with clinical stages.Conclusion:The over-exression of PCNA has a close relationship with the cell proliferation role in cervical cancer,suggesting that PCNA may play an important role in the development of cervix cancer.

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What this paper is about

Objective:To explore the singnificance of proliferating cell nuclear antigen(PCNA) expression in cervical cancer.Methods:Immunohistochemical SP method was opplied to determine the expression of PCNA in 64 cervical cancer tissues and 17 Cervical intraepithelial neoplasia(CIN) cervical tissues and 14 normal cervical tissues.The relationship between the expression and clinical pathology was analyzed.Results:The positive rate of PCNA in cervical cancer was singnificantly higher than that in CIN and normal cervical tissues(P0.05).The expression of PCNA in cervical cancer was associated with clinical stages.Conclusion:The over-exression of PCNA has a close relationship with the cell proliferation role in cervical cancer,suggesting that PCNA may play an important role in the development of cervix cancer.

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Available abstract

Objective:To explore the singnificance of proliferating cell nuclear antigen(PCNA) expression in cervical cancer.Methods:Immunohistochemical SP method was opplied to determine the expression of PCNA in 64 cervical cancer tissues and 17 Cervical intraepithelial neoplasia(CIN) cervical tissues and 14 normal cervical tissues.The relationship between the expression and clinical pathology was analyzed.Results:The positive rate of PCNA in cervical cancer was singnificantly higher than that in CIN and normal cervical tissues(P0.05).The expression of PCNA in cervical cancer was associated with clinical stages.Conclusion:The over-exression of PCNA has a close relationship with the cell proliferation role in cervical cancer,suggesting that PCNA may play an important role in the development of cervix cancer.

Key concepts: Proliferating cell nuclear antigen, Cervical cancer, Immunohistochemistry, Cervical intraepithelial neoplasia, Clinical significance, Pathology, Medicine, Cancer

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