Expression of GLUT1, PCNA Proteins in Cervical Cancer and its Significance

To investigate the expression of GLUT1 and PCNA in cervical cancer and its significance. GLUT1 and PCNA expression were analyzed by immunohistochemistry staining in 120 cases with normal cervical tissue (20 cases), cervical intraepithelial neoplasia(CIN, 40 cases) and cervical cancer (60 cases). Expression of GLUT1, PCNA in difference cervical tissues were different(P0.05). GLUT1 expression in squamous cell carcinoma and adenocarcinoma of cervix were different (P0.05). But it was not related to FIGO, histopathologic, parametrial involvement and pelvic lymph nodes metastasis. PCNA expression was not related to histopathologic type, clinical staging, parametrial involvement and pelvic lymph nodes metastasis(P0.05). [Conclusions] The results suggest that the expression of GLUT1 and PCNA may be involve in cervical cancer development and as the markers for malignant and benign differentiation. The expression of GLUT1 may differ squamous cell carcinoma from adenocarcinoma of cervix and may be a prognostic marker for squamous cell carcinoma.