2008•Shandong yiyaoRequires access
Expression and significance of PTEN and PCNA in cervical squamous carcinoma tissue
Yongxiu Yang
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Abstract
Objective To detect the expression and the significance of PTEN and PCNA in cervica1 squamous carcinoma. Methods PTEN and PCNA expression were detected by immunohistochemistry method in 70 cases of cervical squamous carcinoma and 11 cases of normal cervical specimens. Results Compared with normal cervical tissue, the positive expression rate of PTEN increased and PCNA reduced in cerrical squamous carcinoma. The expression of PTEN and PCNA was negatively related ( r =-0.574, P 0.01). There were significant correlation between the expression of PTEN, PCNA and the histological grade, clinical stage, lymph node metastasis of cervical squamous carcinoma. Conclusion The abnormal high expression of PCNA and low expression of PTEN participate the pathogenesis of cervical carcinoma. PTEN and PCNA protein can be used in clinical diagnose , treatment and prognosis evaluate of cervical squamous carcinoma.