2013•Journal of Apoplexy and Nervous DiseasesRequires access

Association study between a polymorphism of E-selectin gene and cerebral infarction

Peng Gao

Abstract

Objective To detect the E-selectin and A561C gene polymorphism in patients with cerebral infarction.Methods Genotypes of E-selectin in 199 patients with cerebral infarction and 124 controls were typed by PCR-RFIP,SNPrs5361.Results There was significant difference in frequencies of allele and genotype in E-selectin A561C polymorphism between patients group and control group(P0.05).Relative risk analysis indicated that the risk of cerebral infarction in C allele was 5.4 times higher than that in A allele.And the frequency of AC+CC genotypes in patients group was significant higher than control group(P=0.00).Conclusion E-selectin A561C polymorphism was associated with cerebral infarction,and C allele might be a risk factor of cerebral infarction.

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Key concepts: Allele, Genotype, Cerebral infarction, Internal medicine, Polymorphism (computer science), Gene polymorphism, Allele frequency, Medicine