Link of E-selectin polymorphisms and cerebral infarction

Objective To study the relationship between polymorphisms of E-selectin gene and cerebral infarction in Zhuang nationality of Guangxi area. Methods The G98T polymorphism in the exon 2 and the S128R polymorphism in the exon 4 of E-selectin gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis among 187 patients with cerebral infarction, and 210 healthy controls, and the serum level of E-selectin was determined by enzyme-linked immunosorbent assay (ELISA). Results Cerebral infarction group showed significantly higher in serum levels of E-selectin than control group(P0.01), There was significant difference in frequencies of allele and genotype in A561C polymorphism between cerebral infarction and control groups respectively. The relative risk suffered from cerebral infarction of AA genotype was 1.968 times of the AC genotype (OR=1.968,95%CI:1.108～3.495), the serum E-selectin level was significantly higher among carriers of AC genotype as compared with non-carriers(AA genotype) [(59.13±15.92) ng/ml vs (50.46±14.38) ng/ml, P0.01]. Conclusion E-selectin A561C polymorphism is associated with cerebral infarction, and C allele maybe a genetic risk factor of cerebral infarction among Zhuang nationality of Guangxi area. In which the E-selectin AC genotype carriers maybe increase risk by enhancing the E-selectin expression in the pathogenesis of cerebral infarction.