Relationship between the level of serum E-selectin and SER128ARG polymorphisms of E-selectin in patients with acute myocardial infarction

Objective To explore the relationship between the serum level of E-selectin and S128R polymorphisms in the exon 4 of E-selectin gene and acute myocardial infarction (AMI) in local Han peoples. Method The genotype of E-selectin were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 168 patients with acute myocardial infarction and 200 healthy controls,and the serum level of E-selectin was measured by enzyme-linked immunosorbent assay (ELISA).Results There was significant difference in frequencies of allele and genotype in S128R polymorphism between acute myocardial infarction and control groups respectively,The relative risk suffered from acute myocardial infarction of SS genotype was 2.234 times of the SR genotype (OR=2.234,95% CI:1.112～4.437),The serum E-selectin level was significantly higher among carriers of SR genotype as compared with SS genotype (41.65±8.87)μg/L vs (34.23±6.72)μg/L,P0.05.Acute myocardial infarction group showed significantly higher serum level of E-selectin than that of control group,P0.05.Conclusions E-selectin S128R polymorphism was associated with acute myocardial infarction,its polymorphism may affect the serum E-selectin level.R allele may be a risk factor for acute myocardial infarction.