Oxaliplatin in combination with calcium folinate and fluorouracil for treatment of advanced gastric cancer

Objective:To evaluate the effect and safety of oxaliplatin(OXA) combined with calcium folinate(CF) and fluorouracil(5-Fu) regimen for patients with advanced gastric cancer.Methods:OXA 130 mg/m~2 (2 hours infusion on the first day),CF 200 mg/m~2 (1 hour infusion for 5 days) and 5-Fu 350 mg/m~2(4 hours infusion on the first day) were administered and the regimen was repeated every 3 weeks.The efficacy was evaluated after two repeated cycles were completed.Results:Twenty-eight patients were included in the study.One patient achieved CR,11 PR,10 SD and 6 PD.The overall response rate was 42.9%.The main adverse effects were bone marrow suppression,nausea,vomiting and neurosensory toxicity.Conclusions:OXA-CF-5-Fu regimen is highly effective for treatment of advanced gastric cancer with mild toxicity.