Clinical study of combined oxaliplatin with 5-fluorouracil and calcium folinate in advanced gastric cancer

Objective:To evaluate the efficacy and toxicity of Oxaliplatin in combination with calcium folinate and 5-Fluorouracil continuous infusion in treatment of advanced gastric cancer.Methods:Oxaliplatin 100mg/m2 in 2h d1;calcium folinate 200 mg/m2 in 2h d1,d2;after that 5-Fu 400mg/m2 bolus on d1,d2,and then 5-Fu 600 mg/m2c.i.v using an ambulatory pump for 22 hours on d1,d2;2 weeks for one cycle.The efficacy was evaluated two weeks after administration.Results:Two patient reached complete response(4.35%),19 partial response(41.30%),17 stable disease(36.96%),and8 with progression after treatment(17.39%),response rate for the whole group was 45.65%.Overall response rates for patients untreated and treated previously were 57.69% and 33.33% re spectively,no significant difference existed between the two groups(P0.05).Median response time was 6.3 months and median survival time was 8.5 months,one year survival rate was 52.17%.No treatment-related death occurred.The major toxicity were peripheral neurotoxicity(69.57%),myelosuppression(30.43%),nausea/vomiting(39.13%).Conclusion:Oxaliplatin plus calcium folinate and 5-fluorouracil continuous infusion combination therapy is effective for advanced gastric cancer.