Distribution and drug resistance of pathogenic bacteria from cultured blood of children in Shenzhen

Objective To investigate the distribution and antibiotic resistance of pathogenic bacteria isolated from blood samples of children in shenzhen district and to provide essential information regarding the selection of antibiotic therapy for septicaemia. Methods All the blood sample were isolated from children in Shenzhen Children's Hospital between Janunary 2007 and March 2008, And were cultured with Bact/AIERT 3D automatic system, analyzed with VITEK32 system. Results 192 strains of bacteria were isolated, 144 is gram positive bacteria trains(accounted for 75%),46 is gram negative bacteria trains(accounted for 24%),2 is fungi strains (accounted for 1%). The commonest strain is coagulase negative staphylococcus(121 strains), followed by Escherichia coli(12 strains), Klebsiella spp(10 strains), typhoid bacilli(8 strains)and pseudomona aeruginose(7 strains). The antibiotic resistance rate of coagulase negative staphylococcus to penicillin, ampicillin/sulbactam、erythromycin are all more than 80%, but sensitive to vancomycin, moxifloxacon, linezoid, nitrofurantoin. The antibiotic resistance rate of gram positive bacteria trains to ampicillin,compound sulfamethoxazole, cefepime are between 50% and 80%, but sensitive to imipenem, levofloxacin, piperacillin/tazobactam, nitrofurantoin, amikacin. Conclusion Coagulase negative staphylococcus was the commonest strains of children septicaemia in Shenzhen district, It was important for reasonable use of antibiotics to know distribution and antibiotic resistance of pathogens.