Analysis of Distribution and Antibiotic Resistance of Pathogens from Neonatal Blood Culture in Zhejiang Province

Objective To investigate the distribution and antibiotic resistance of pathogens isolated from neonatal blood culture in Zhejiang Province.Methods 5442 blood samples were cultured from the newborn ward of Children's Hospital of Zhejiang University School of Medicine,VITEK automicroscan was used for strains identification and drug sensitivity test.Results 301 pathogenic strains were isolated from 5442 specimens and the positive rate was 5.5%.Among them,267 strains were gram-positive bacteria(88.7%),and the coagulase negative staphylococcus was dominant(78.41%).33 strains were gram-negative bacteria(11.0%),and the E.coli was most frequently isolated(36.4% of gram-negative bacteria).The results of drug sensitivity test showed that the resistance rate of gram-positive bacteria to Penicillin G was the highest,the next were Oxacillin,Cefazolin,Ampinicillin/Sulbactam and Erythromycin.Among gram-negative bacteria,the positive rates of E.coli and Klebsiella pneumoniae that produce Extent-spectrum β-lactamases(ESBLs) were about 41.67% and 87.5%,respectively.And the resistance rates of them to Ciprofloxacin,Amikacin,Levofloxacin,Piperacillin/Tazobactam and Imipenem were rather lower.Conclusion Gram-positive bacteria were the main pathogen causing neonatal septicemia in Zhejiang Province.Among them,coagulase negative staphylococcus is the main cause,and E.coli follows.The situation of antibiotic resistance was serious.