Experimental Study on Increasing Effect and Decreasing its Side-effect of Cisplatin of LiuJunZi Decoction

Objective To observe the chemotherapy-increasing effect and toxicity-decreasing of LiujunZi decoction in H22 carcinomatous mice.Methods Taking out ascites under asepsis which grew well for 9 days as the source of carcinoma and diluting it with salt water,then injecting 0.2 m1 diluent into the subcutaneous tissue of the right axilla of mice 24 hours after injection,mice were grouped as control group,Cisplatin group,ZhenQiFuZheng capsule combined with Cisplatin groups,and LiuJunZi Decoction(high,middle dose) combined with Cisplatin groups.After 10 days treatment,the tumor inhibition rate was calculated,the content of malondialdehyde(MDA) in kidney,nitric oxide(NO) in spleen and the level of serum urea nitrogen(BUN) and immunoglobulin(Ig) were detected.Results LiuJunZi Decoction could elevate the tumor-supression rate of Cisplatin on H22 carcinomatous mice(P﹤0.05),antagonize the toxic and side effects of Cisplatin the atrophy of spleen and thoracic gland,the decrease of IgG and IgM.Also it could decrease MDA in kidney,NO in spleen of carcinomatous and serum BUN of mice(P﹤0.05 or P﹤0.01).Conclusion LiuJunZi Decoction has the effect of increasing the effect of chemotherapy and decreasing its side-effect of Cisplatin in H22 carcinomatous mice.