A Clinical Study of Using Accompanied Lisinopril with Metoprolol in the Patients with Congestive Heart Failure

Objective To evaluate the therapeutic efficacy of Lisinopril accompanied with metoprolol in the patients with congestive heart failure (CHF). Methods 96 patients with CHF were randomly divided into group A (n= 46) who had taken conventional treatment of digitalis and diuretics and group B ( n = 50) who were given Lisinopril (10mg·d-1) and metoprolol (12.5 to 100 mg·d-1) on the conventional therapy. The herapeutic period was 6 months.Results After treatment, cardiac function (NYHA) improved ; blood pressure , heart rate , cardiothoracic ratio , left ventricular diastolic ending diameter (LVDd) and left aurial diameter (LAd) all decreased ; left ventricular ejectional fraction (LVEF) increased significantly(P0.05) in group B comparing with those in group A. There were few side effects and patients'tolerance was perfect in Group B.Conclusion The therapeutic efficacy of Lisinopril accompanied with metoprolol inthe patients with congestive heart failure (CHF) is satisfactory. There are few side effects.