Treatment effect of naftifine/ketoconazole cream to tinea cruris

Objective To observe the clinical efficacy in the treatment of tinea cruris by naftifine/ketoconazole cream.Methods One hundred and sixty patients with tinea versicolor were randomly divided into trial group and control group.Naftifine / ketoconazole cream were applied in the trial group.Miconazole nitrate cream were applied in the control group.Both were used in the morning and evening.Clinical and mycological therapeutic effects were evaluated in 2 weeks of treatment and in 3 weeks of drug withdrawal.Results The effective rates in the treatment group and control group were 92.5% and 76.25% respectively,there was significant difference between the two groups(P 0.05).Fungs clearance rate of the treatment group was 97.50% whereas control group was 87.5% at the end of 2 weeks treatment.There was significant difference between the two groups(P 0.05).The effective rates in the treatment group and control group were 96.25% and 75.00% respectively,there was significant difference between the two groups(P 0.05).Fungs clearance rate of the treatment group was 97.50% whereas control group was 85.00% at discontinued 3 weeks.There was significant difference between the two groups(P 0.05).No obvious adverse reaction.Conclusion Naftifine / ketoconazole cream in treatment of tinea cruris is effect and safe.