2009•Jiangsu Medical JournalRequires access

Effects of rosiglitazone on renal TGF-β and collagen-IV of diabetic rats

Wei Li

Abstract

Objective To investigate the effects of rosiglitazone on renal TGF-β and collagen-Ⅳ in diabetic rats.Methods Forty rats were randomized into 3 groups of normal control rats(group C),diabetic rats(group DC)and diabetic rats treated with rosiglitazone(group DR).After 10 weeks,blood glucose and microalbuminuria were measured and pathologic change of the kidney was observed.TGF-β and collagen-Ⅳ expressions in kidneny cortex were observed by immunohistochemistry.Results Kidney index,microalbuminuria and the expressions of TGF-β and collagen-Ⅳ in group DC were significantly higher than those in group C and group DR(P0.01).Conclusion Rosiglitazone has a protective effect on the kidney in diabetic rats through downregulating the expression of TGF-β and collagen-Ⅳ.

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Key concepts: Rosiglitazone, Medicine, Internal medicine, Endocrinology, Microalbuminuria, Kidney, Transforming growth factor, Diabetic nephropathy